Gene signature of antigen processing and presentation machinery predicts response to checkpoint blockade in non-small cell lung cancer (NSCLC) and melanoma

BACKGROUND: Limited data exist on the role of alterations in HLA Class I antigen processing and presentation machinery in mediating response to immune checkpoint blockade (ICB). METHODS: This retrospective cohort study analyzed transcriptional profiles from pre-treatment tumor samples of 51 chemothe...

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Publicat a:J Immunother Cancer
Autors principals: Thompson, Jeffrey C, Davis, Christiana, Deshpande, Charuhas, Hwang, Wei-Ting, Jeffries, Seth, Huang, Alexander, Mitchell, Tara C, Langer, Corey J, Albelda, Steven M
Format: Artigo
Idioma:Inglês
Publicat: BMJ Publishing Group 2020
Matèries:
Immunotherapy Biomarkers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7542663/
https://ncbi.nlm.nih.gov/pubmed/33028693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-000974
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