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Analysis of the Overdispersed Clock in the Short-Term Evolution of Hepatitis C Virus: Using the E1/E2 Gene Sequences to Infer Infection Dates in a Single Source Outbreak

The assumption of a molecular clock for dating events from sequence information is often frustrated by the presence of heterogeneity among evolutionary rates due, among other factors, to positively selected sites. In this work, our goal is to explore methods to estimate infection dates from sequence...

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Bibliographic Details
Published in:Mol Biol Evol
Main Authors: Wróbel, Borys, Torres-Puente, Manuela, Jiménez, Nuria, Bracho, María Alma, García-Robles, Inmaculada, Moya, Andrés, González-Candelas, Fernando
Format: Artigo
Language:Inglês
Published: Society for Molecular Biology and Evolution 2006
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7542578/
https://ncbi.nlm.nih.gov/pubmed/16585120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msk012
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