Defects in mRNA translation in LRRK2-mutant hiPSC-derived dopaminergic neurons leads to dysregulated calcium homeostasis

The G2019S mutation in leucine-rich repeat kinase 2 (LRRK2) is a common cause of familial Parkinson’s disease (PD). This mutation results in dopaminergic neurodegeneration via dysregulated protein translation, although how alterations in protein synthesis contributes to neurodegeneration in human ne...

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Publicado no:Cell Stem Cell
Main Authors: Kim, Jungwoo Wren, Yin, Xiling, Jhaldiyal, Aanishaa, Khan, Mohammed Repon, Martin, Ian, Xie, Zhong, Perez-Rosello, Tamara, Kumar, Manoj, Abalde-Atristain, Leire, Xu, Jinchong, Chen, Li, Eacker, Stephen M., Surmeier, D. James, Ingolia, Nicholas T., Dawson, Ted M., Dawson, Valina L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7542555/
https://ncbi.nlm.nih.gov/pubmed/32846140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2020.08.002
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