Paclitaxel exposure downregulates miR-522 expression and its downregulation induces paclitaxel resistance in ovarian cancer cells

Paclitaxel resistance is a critical challenge in ovarian cancer treatment. This study aimed to identify microRNAs (miRNAs) that modulate paclitaxel resistance for use as potential therapeutic targets in such settings. Paclitaxel-resistant cell lines were established using two ovarian cancer cell lin...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Miyamoto, Mayuko, Sawada, Kenjiro, Nakamura, Koji, Yoshimura, Akihiko, Ishida, Kyoso, Kobayashi, Masaki, Shimizu, Aasa, Yamamoto, Misa, Kodama, Michiko, Hashimoto, Kae, Kimura, Tadashi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7542453/
https://ncbi.nlm.nih.gov/pubmed/33028939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-73785-8
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