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PIK3IP1 promotes extrafollicular class switching in T-dependent immune responses

PI3 kinase (PI3K) plays multiple roles throughout the life a B cell. As such, its signaling is tightly regulated. The importance of this is illustrated by the fact that both loss and gain of function mutations in PI3K can cause immunodeficiency in humans. PIK3IP1, also known as TrIP, is a transmembr...

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Bibliografiske detaljer
Udgivet i:J Immunol
Main Authors: Ottens, Kristina, Schneider, Jalyn, Kane, Lawrence P., Satterthwaite, Anne B.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7541772/
https://ncbi.nlm.nih.gov/pubmed/32887751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.2000584
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