Small Molecule Inhibitor of 8-oxoguanine DNA Glycosylase 1 Regulates Inflammatory Responses during P. aeruginosa Infection

The DNA repair enzyme 8-oxoguanine DNA glycosylase 1 (OGG1), which excises 8-oxo-7,8-dihydroguanine (8-oxoG) lesions induced in DNA by reactive oxygen species, has been linked to the pathogenesis of lung diseases associated with bacterial infections. A recently developed small molecule, SU0268, has...

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Bibliographic Details
Published in:J Immunol
Main Authors: Qin, Shugang, Lin, Ping, Wu, Qun, Pu, Qinqin, Zhou, Chuanmin, Wang, Biao, Gao, Pan, Wang, Zhihan, Gao, Ashley, Overby, Madison, Yang, Jinliang, Jiang, Jianxin, Wilson, David L., Tahara, Yu-ki, Kool, Eric T., Xia, Zhenwei, Wu, Min
Format: Artigo
Language:Inglês
Published: 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7541742/
https://ncbi.nlm.nih.gov/pubmed/32929043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1901533
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