SWELL1 regulates skeletal muscle cell size, intracellular signaling, adiposity and glucose metabolism

Maintenance of skeletal muscle is beneficial in obesity and Type 2 diabetes. Mechanical stimulation can regulate skeletal muscle differentiation, growth and metabolism; however, the molecular mechanosensor remains unknown. Here, we show that SWELL1 (Lrrc8a) functionally encodes a swell-activated ani...

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Vydáno v:eLife
Hlavní autoři: Kumar, Ashutosh, Xie, Litao, Ta, Chau My, Hinton, Antentor O, Gunasekar, Susheel K, Minerath, Rachel A, Shen, Karen, Maurer, Joshua M, Grueter, Chad E, Abel, E Dale, Meyer, Gretchen, Sah, Rajan
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2020
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7541086/
https://ncbi.nlm.nih.gov/pubmed/32930093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.58941
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