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HMGB1-induced autophagy promotes extracellular matrix degradation leading to intervertebral disc degeneration

Intervertebral disc degeneration (IDD) remains a leading cause of adult disability. High mobility group box l (HMGB1) is a nuclear DNA-binding protein and acts as a central mediator of inflammation. The purpose of this study was to investigate the effect of HMGB1 in IDD. In our study, IDD interverte...

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Detalhes bibliográficos
Publicado no:Int J Clin Exp Pathol
Main Authors: Fu, Biao, Lu, Xia, Zhao, Er-Yang, Wang, Ji-Xin, Peng, Si-Min
Formato: Artigo
Idioma:Inglês
Publicado em: e-Century Publishing Corporation 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7539879/
https://ncbi.nlm.nih.gov/pubmed/33042328
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