Adaptation and selection shape clonal evolution of tumors during residual disease and recurrence

The survival and recurrence of residual tumor cells following therapy constitutes one of the biggest obstacles to obtaining cures in breast cancer, but it remains unclear how the clonal composition of tumors changes during relapse. We use cellular barcoding to monitor clonal dynamics during tumor re...

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Vydáno v:Nat Commun
Hlavní autoři: Walens, Andrea, Lin, Jiaxing, Damrauer, Jeffrey S., McKinney, Brock, Lupo, Ryan, Newcomb, Rachel, Fox, Douglas B., Mabe, Nathaniel W., Gresham, Jeremy, Sheng, Zhecheng, Sibley, Alexander B., De Buysscher, Tristan, Kelkar, Hemant, Mieczkowski, Piotr A., Owzar, Kouros, Alvarez, James V.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7539014/
https://ncbi.nlm.nih.gov/pubmed/33024122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18730-z
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