Frequency of the TP53 R337H variant in sporadic breast cancer and its impact on genomic instability

The R337H is a TP53 germline pathogenic variant that has been associated with several types of cancers, including breast cancer. Our main objective was to determine the frequency of the R337H variant in sporadic breast cancer patients from Paraná state, South Brazil, its association with prognosis a...

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Publicado no:Sci Rep
Main Authors: Mathias, Carolina, Bortoletto, Stéfanne, Centa, Ariana, Komechen, Heloisa, Lima, Rubens S., Fonseca, Aline S., Sebastião, Ana Paula, Urban, Cícero A., Soares, Emerson W. S., Prando, Carolina, Figueiredo, Bonald C., Cavalli, Iglenir J., Cavalli, Luciane R., Ribeiro, Enilze M. F. S.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7539008/
https://ncbi.nlm.nih.gov/pubmed/33024147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-73282-y
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