Proteostasis Regulation in the Endoplasmic Reticulum: An Emerging Theme in the Molecular Pathology and Therapeutic Management of Familial Hypercholesterolemia

Familial hypercholesterolemia (FH) is an autosomal genetic disease characterized by high serum low-density lipoprotein (LDL) content leading to premature coronary artery disease. The main genetic and molecular causes of FH are mutations in low-density lipoprotein receptor gene (LDLR) resulting in th...

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Vydáno v:Front Genet
Hlavní autoři: Oommen, Deepu, Kizhakkedath, Praseetha, Jawabri, Aseel A., Varghese, Divya Saro, Ali, Bassam R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020
Témata:
Genetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7538668/
https://ncbi.nlm.nih.gov/pubmed/33173538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2020.570355
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