IL-12 DNA Displays Efficient Adjuvant Effects Improving Immunogenicity of Ag85A in DNA Prime/MVA Boost Immunizations

Mycobacterium tuberculosis (Mtb) infection is one of the leading causes of death worldwide. The Modified Vaccinia Ankara (MVA) vaccine vector expressing the mycobacterial antigen 85A (MVA85A) was demonstrated to be safe, although it did not improve BCG efficacy, denoting the need to search for impro...

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Bibliographische Detailangaben
Veröffentlicht in:Front Cell Infect Microbiol
Hauptverfasser: Morelli, María Paula, Del Medico Zajac, María Paula, Pellegrini, Joaquín Miguel, Amiano, Nicolás Oscar, Tateosian, Nancy Liliana, Calamante, Gabriela, Gherardi, María Magdalena, García, Verónica Edith
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020
Schlagworte:
Cellular and Infection Microbiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7538621/
https://ncbi.nlm.nih.gov/pubmed/33072631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2020.581812
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