IL-12 DNA Displays Efficient Adjuvant Effects Improving Immunogenicity of Ag85A in DNA Prime/MVA Boost Immunizations

Mycobacterium tuberculosis (Mtb) infection is one of the leading causes of death worldwide. The Modified Vaccinia Ankara (MVA) vaccine vector expressing the mycobacterial antigen 85A (MVA85A) was demonstrated to be safe, although it did not improve BCG efficacy, denoting the need to search for impro...

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Dettagli Bibliografici
Pubblicato in:Front Cell Infect Microbiol
Autori principali: Morelli, María Paula, Del Medico Zajac, María Paula, Pellegrini, Joaquín Miguel, Amiano, Nicolás Oscar, Tateosian, Nancy Liliana, Calamante, Gabriela, Gherardi, María Magdalena, García, Verónica Edith
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020
Soggetti:
Cellular and Infection Microbiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7538621/
https://ncbi.nlm.nih.gov/pubmed/33072631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2020.581812
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