Poly-ion complex (PIC) formation of heparin and polyamines: PIC with tetrakis (3-aminopropyl) ammonium allows sustained release of heparin

Physical mixtures of cationic polymers and heparin have been developed to overcome the limitations of unfractionated heparin. In this study, we found that heparin associates with natural polyamines in water, resulting in the generation of a poly-ion complex (PIC). PIC formation (or stability) was in...

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Dades bibliogràfiques
Publicat a:Heliyon
Autors principals: Ito, Daichi, Ge, Dan, Kogure, Noriyuki, Manaka, Hitomi, Terui, Yusuke, Takayama, Hiromitsu, Linhardt, Robert J., Toida, Toshihiko, Higashi, Kyohei
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7538075/
https://ncbi.nlm.nih.gov/pubmed/33043161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.heliyon.2020.e05168
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