Poly-ion complex (PIC) formation of heparin and polyamines: PIC with tetrakis (3-aminopropyl) ammonium allows sustained release of heparin

Physical mixtures of cationic polymers and heparin have been developed to overcome the limitations of unfractionated heparin. In this study, we found that heparin associates with natural polyamines in water, resulting in the generation of a poly-ion complex (PIC). PIC formation (or stability) was in...

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Bibliografische gegevens
Gepubliceerd in:Heliyon
Hoofdauteurs: Ito, Daichi, Ge, Dan, Kogure, Noriyuki, Manaka, Hitomi, Terui, Yusuke, Takayama, Hiromitsu, Linhardt, Robert J., Toida, Toshihiko, Higashi, Kyohei
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2020
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7538075/
https://ncbi.nlm.nih.gov/pubmed/33043161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.heliyon.2020.e05168
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