Poly-ion complex (PIC) formation of heparin and polyamines: PIC with tetrakis (3-aminopropyl) ammonium allows sustained release of heparin

Physical mixtures of cationic polymers and heparin have been developed to overcome the limitations of unfractionated heparin. In this study, we found that heparin associates with natural polyamines in water, resulting in the generation of a poly-ion complex (PIC). PIC formation (or stability) was in...

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Vydáno v:Heliyon
Hlavní autoři: Ito, Daichi, Ge, Dan, Kogure, Noriyuki, Manaka, Hitomi, Terui, Yusuke, Takayama, Hiromitsu, Linhardt, Robert J., Toida, Toshihiko, Higashi, Kyohei
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2020
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7538075/
https://ncbi.nlm.nih.gov/pubmed/33043161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.heliyon.2020.e05168
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