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Buffering and total calcium levels determine the presence of oscillatory regimes in cardiac cells

Calcium oscillations and waves induce depolarization in cardiac cells which are believed to cause life-threathening arrhythimas. In this work, we study the conditions for the appearance of calcium oscillations in both a detailed subcellular model of calcium dynamics and a minimal model that takes in...

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Veröffentlicht in:PLoS Comput Biol
Hauptverfasser: Marchena, Miquel, Echebarria, Blas, Shiferaw, Yohannes, Alvarez-Lacalle, Enrique
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7537911/
https://ncbi.nlm.nih.gov/pubmed/32970668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1007728
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