Transmembrane TNF drives osteoproliferative joint inflammation reminiscent of human spondyloarthritis

TNF plays a key role in immune-mediated inflammatory diseases including rheumatoid arthritis (RA) and spondyloarthritis (SpA). It remains incompletely understood how TNF can lead to different disease phenotypes such as destructive peripheral polysynovitis in RA versus axial and peripheral osteoproli...

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Pubblicato in:J Exp Med
Autori principali: Kaaij, Merlijn H., van Tok, Melissa N., Blijdorp, Iris C., Ambarus, Carmen A., Stock, Michael, Pots, Désiree, Knaup, Véronique L., Armaka, Marietta, Christodoulou-Vafeiadou, Eleni, van Melsen, Tessa K., Masdar, Huriatul, Eskes, Harry J.P.P., Yeremenko, Nataliya G., Kollias, George, Schett, Georg, Tas, Sander W., van Duivenvoorde, Leonie M., Baeten, Dominique L.P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Rockefeller University Press 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7537402/
https://ncbi.nlm.nih.gov/pubmed/32662821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20200288
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