Ovarian Cancer Risk Variants Are Enriched in Histotype-Specific Enhancers and Disrupt Transcription Factor Binding Sites

Quantifying the functional effects of complex disease risk variants can provide insights into mechanisms underlying disease biology. Genome-wide association studies have identified 39 regions associated with risk of epithelial ovarian cancer (EOC). The vast majority of these variants lie in the non-...

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Udgivet i:Am J Hum Genet
Main Authors: Jones, Michelle R., Peng, Pei-Chen, Coetzee, Simon G., Tyrer, Jonathan, Reyes, Alberto Luiz P., Corona, Rosario I., Davis, Brian, Chen, Stephanie, Dezem, Felipe, Seo, Ji-Heui, Kar, Siddartha, Dareng, Eileen, Berman, Benjamin P., Freedman, Matthew L., Plummer, Jasmine T., Lawrenson, Kate, Pharoah, Paul, Hazelett, Dennis J., Gayther, Simon A.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7536645/
https://ncbi.nlm.nih.gov/pubmed/32946763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2020.08.021
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