Cell-type-specific enrichment of risk-associated regulatory elements at ovarian cancer susceptibility loci

Understanding the regulatory landscape of the human genome is a central question in complex trait genetics. Most single-nucleotide polymorphisms (SNPs) associated with cancer risk lie in non-protein-coding regions, implicating regulatory DNA elements as functional targets of susceptibility variants....

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Библиографические подробности
Опубликовано в: :Hum Mol Genet
Главные авторы: Coetzee, Simon G., Shen, Howard C., Hazelett, Dennis J., Lawrenson, Kate, Kuchenbaecker, Karoline, Tyrer, Jonathan, Rhie, Suhn K., Levanon, Keren, Karst, Alison, Drapkin, Ronny, Ramus, Susan J., Couch, Fergus J., Offit, Kenneth, Chenevix-Trench, Georgia, Monteiro, Alvaro N.A., Antoniou, Antonis, Freedman, Matthew, Coetzee, Gerhard A., Pharoah, Paul D.P., Noushmehr, Houtan, Gayther, Simon A.
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2015
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Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4459387/
https://ncbi.nlm.nih.gov/pubmed/25804953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv101
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