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Inferring Gene-by-Environment Interactions with a Bayesian Whole-Genome Regression Model

The contribution of gene-by-environment (GxE) interactions for many human traits and diseases is poorly characterized. We propose a Bayesian whole-genome regression model for joint modeling of main genetic effects and GxE interactions in large-scale datasets, such as the UK Biobank, where many envir...

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Publicat a:Am J Hum Genet
Autors principals: Kerin, Matthew, Marchini, Jonathan
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7536582/
https://ncbi.nlm.nih.gov/pubmed/32888427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2020.08.009
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