Cdc6 disruption leads to centrosome abnormalities and chromosome instability in pancreatic cancer cells

Cell division cycle 6 (Cdc6) plays key roles in regulating DNA replication, and activation and maintenance of cell cycle check points. In addition, Cdc6 exerts oncogenic properties via genomic instability associated with incomplete DNA replication. This study aimed to examine the effects of Cdc6 on...

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Vydáno v:Sci Rep
Hlavní autoři: Youn, Yuna, Lee, Jong-chan, Kim, Jaihwan, Kim, Jae Hyeong, Hwang, Jin-Hyeok
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7536414/
https://ncbi.nlm.nih.gov/pubmed/33020506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-73474-6
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