Isodeoxyelephantopin Inactivates Thioredoxin Reductase 1 and Activates ROS-Mediated JNK Signaling Pathway to Exacerbate Cisplatin Effectiveness in Human Colon Cancer Cells

Colon cancer is one of the leading causes of cancer-related death in the world. The development of new drugs and therapeutic strategies for patients with colon cancer are urgently needed. Isodeoxyelephantopin (ESI), a sesquiterpene lactone isolated from the medicinal plant Elephantopus scaber L., ha...

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Vydáno v:Front Cell Dev Biol
Hlavní autoři: Hong, Lin, Chen, Jundixia, Wu, Fang, Wu, Fengjiao, Shen, Xin, Zheng, Peisen, Shao, Rongrong, Lu, Kongqin, Liu, Zhiguo, Chen, Daoxing, Liang, Guang, Cai, Yuepiao, Zou, Peng, Xia, Yiqun
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020
Témata:
Cell and Developmental Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7536313/
https://ncbi.nlm.nih.gov/pubmed/33072762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2020.580517
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