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Monitoring and modeling of lymphocytic leukemia cell bioenergetics reveals decreased ATP synthesis during cell division

The energetic demands of a cell are believed to increase during mitosis, but the rates of ATP synthesis and consumption during mitosis have not been quantified. Here, we monitor mitochondrial membrane potential of single lymphocytic leukemia cells and demonstrate that mitochondria hyperpolarize from...

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Vydáno v:Nat Commun
Hlavní autoři: Kang, Joon Ho, Katsikis, Georgios, Li, Zhaoqi, Sapp, Kiera M., Stockslager, Max A., Lim, Daniel, Vander Heiden, Matthew G., Yaffe, Michael B., Manalis, Scott R., Miettinen, Teemu P.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7536222/
https://ncbi.nlm.nih.gov/pubmed/33020492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18769-y
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