AI26 inhibits the ADP-ribosylhydrolase ARH3 and suppresses DNA damage repair

The ADP-ribosylhydrolase ARH3 plays a key role in DNA damage repair, digesting poly(ADP-ribose) and removing ADP-ribose from serine residues of the substrates. Specific inhibitors that selectively target ARH3 would be a useful tool to examine DNA damage repair, as well as a possible strategy for tum...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Liu, Xiuhua, Xie, Rong, Yu, Lily L., Chen, Shih-Hsun, Yang, Xiaoyun, Singh, Anup K., Li, Hongzhi, Wu, Chen, Yu, Xiaochun
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2020
Subjects:
DNA and Chromosomes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7535916/
https://ncbi.nlm.nih.gov/pubmed/32753484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.012801
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