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Evaluation of active Rac1 levels in cancer cells: A case of misleading conclusions from immunofluorescence analysis
A large number of aggressive cancer cell lines display elevated levels of activated Rac1, a small GTPase widely implicated in cytoskeleton reorganization, cell motility, and metastatic dissemination. A commonly accepted methodological approach for detecting Rac1 activation in cancer cells involves t...
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| Veröffentlicht in: | J Biol Chem |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7535912/ https://ncbi.nlm.nih.gov/pubmed/32817335 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013919 |
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