4CPS-147 Determination of tpmt and nudt15 polymorphisms in a patient with common variable immunodeficiency

BACKGROUND: The lack of activity in thiopurine-methyltrasnferase (TPMT) is related to severe toxicity in the use of thiopurines (azathioprine, 6-mercaptopurine and thioguanine). This lack of activity is often due to genetic polymorphisms located at TPMT, and recently demonstrated in NUDT15 genes. PU...

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Dettagli Bibliografici
Pubblicato in:Eur J Hosp Pharm
Autori principali: Gil, S García, Palau, M Carrillo, Sánchez, V Casañas, Diaz, R Ramos, Nicolás, F Gutiérrez, Casariego, GJ Nazco, Sánchez, P Yanes, Romero, MM Viña
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMJ Group 2018
Soggetti:
Section 4: Clinical pharmacy services
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7535486/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/ejhpharm-2018-eahpconf.238
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