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Quality control of 40S ribosome head assembly ensures scanning competence
During translation initiation, 40S ribosomes scan the mRNA until they encounter the start codon, where conformational changes produce a translation-competent 80S complex. Destabilizing the scanning complex results in misinitiation at non-AUG codons, demonstrating its importance for fidelity. Here, w...
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| Udgivet i: | J Cell Biol |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Rockefeller University Press
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7534925/ https://ncbi.nlm.nih.gov/pubmed/33007085 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.202004161 |
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