Neuron-Derived Estrogen Is Critical for Astrocyte Activation and Neuroprotection of the Ischemic Brain

17β-Estradiol (E2) is produced from androgens via the action of the enzyme aromatase. E2 is known to be made in neurons in the brain, but the functions of neuron-derived E2 in the ischemic brain are unclear. Here, we used a forebrain neuron-specific aromatase KO (FBN-ARO-KO) mouse model to deplete n...

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Vydáno v:J Neurosci
Hlavní autoři: Lu, Yujiao, Sareddy, Gangadhara R., Wang, Jing, Zhang, Quanguang, Tang, Fu-Lei, Pratap, Uday P., Tekmal, Rajeshwar R., Vadlamudi, Ratna K., Brann, Darrell W.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2020
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7534920/
https://ncbi.nlm.nih.gov/pubmed/32817249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0115-20.2020
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