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Regulation of hepatic insulin signaling and glucose homeostasis by sphingosine kinase 2

Sphingolipid dysregulation is often associated with insulin resistance, while the enzymes controlling sphingolipid metabolism are emerging as therapeutic targets for improving insulin sensitivity. We report herein that sphingosine kinase 2 (SphK2), a key enzyme in sphingolipid catabolism, plays a cr...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Aji, Gulibositan, Huang, Yu, Ng, Mei Li, Wang, Wei, Lan, Tian, Li, Min, Li, Yufei, Chen, Qi, Li, Rui, Yan, Sishan, Tran, Collin, Burchfield, James G., Couttas, Timothy A., Chen, Jinbiao, Chung, Long Hoa, Liu, Da, Wadham, Carol, Hogg, Philip J., Gao, Xin, Vadas, Mathew A., Gamble, Jennifer R., Don, Anthony S., Xia, Pu, Qi, Yanfei
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2020
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Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7533871/
https://ncbi.nlm.nih.gov/pubmed/32917816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2007856117
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