Suboptimal SARS-CoV-2−specific CD8(+) T cell response associated with the prominent HLA-A*02:01 phenotype

An improved understanding of human T cell-mediated immunity in COVID-19 is important for optimizing therapeutic and vaccine strategies. Experience with influenza shows that infection primes CD8(+) T cell memory to peptides presented by common HLA types like HLA-A2, which enhances recovery and dimini...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Habel, Jennifer R., Nguyen, Thi H. O., van de Sandt, Carolien E., Juno, Jennifer A., Chaurasia, Priyanka, Wragg, Kathleen, Koutsakos, Marios, Hensen, Luca, Jia, Xiaoxiao, Chua, Brendon, Zhang, Wuji, Tan, Hyon-Xhi, Flanagan, Katie L., Doolan, Denise L., Torresi, Joseph, Chen, Weisan, Wakim, Linda M., Cheng, Allen C., Doherty, Peter C., Petersen, Jan, Rossjohn, Jamie, Wheatley, Adam K., Kent, Stephen J., Rowntree, Louise C., Kedzierska, Katherine
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7533701/
https://ncbi.nlm.nih.gov/pubmed/32913053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2015486117
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