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SDF1/CXCR4 axis facilitates the angiogenesis via activating the PI3K/AKT pathway in degenerated discs

Symptomatic degenerative disc disease (DDD) is considered the leading cause of chronic lower back pain (LBP). As one of the main features of intervertebral disc degeneration (IDD), vascular ingrowth plays a crucial role in the progression of LBP. Stromal cell-derived factor 1 (SDF1) and its receptor...

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Detalhes bibliográficos
Publicado no:Mol Med Rep
Main Authors: Zhang, Hanxiang, Wang, Peng, Zhang, Xiang, Zhao, Wenrui, Ren, Honglei, Hu, Zhenming
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7533460/
https://ncbi.nlm.nih.gov/pubmed/32901877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/mmr.2020.11498
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