Direct Delivery of MicroRNA96 to the Lungs Reduces Progression of Sugen/Hypoxia-Induced Pulmonary Hypertension in the Rat

The 5HT1B receptor (5HT1BR) contributes to the pathogenic effects of serotonin in pulmonary arterial hypertension. Here, we determine the effect of a microRNA96 (miR96) mimic delivered directly to the lungs on development of severe pulmonary hypertension in rats. Female rats were dosed with sugen (3...

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Библиографические подробности
Опубликовано в: :Mol Ther Nucleic Acids
Главные авторы: Docherty, Craig K., Denver, Nina, Fisher, Simon, Nilsen, Margaret, Hillyard, Dianne, Openshaw, Rebecca L., Labazi, Hicham, MacLean, Margaret R.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society of Gene & Cell Therapy 2020
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Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7533346/
https://ncbi.nlm.nih.gov/pubmed/33230444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2020.09.002
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