Mechanism of action biomarkers predicting response to AKT inhibition in the I-SPY 2 breast cancer trial

The AKT inhibitor MK2206 (M) was evaluated in I-SPY 2 and graduated in the HER2+, HR−, and HR− HER2+ signatures. We hypothesized that AKT signaling axis proteins/genes may specifically predict response to M and tested 26 phospho-proteins and 10 genes involved in AKT-mTOR-HER signaling; in addition,...

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Publicat a:NPJ Breast Cancer
Autors principals: Wolf, Denise M., Yau, Christina, Wulfkuhle, Julia, Brown-Swigart, Lamorna, Gallagher, Rosa I., Magbanua, Mark Jesus M., O’Grady, Nick, Hirst, Gillian, Asare, Smita, Tripathy, Debu, Berry, Don, Esserman, Laura, Chien, A. Jo, Petricoin, Emanuel F., van ‘t Veer, Laura
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7532145/
https://ncbi.nlm.nih.gov/pubmed/33083527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41523-020-00189-2
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