DNA repair deficiency biomarkers and the 70-gene ultra-high risk signature as predictors of veliparib/carboplatin response in the I-SPY 2 breast cancer trial

Veliparib combined with carboplatin (VC) was an experimental regimen evaluated in the biomarker-rich neoadjuvant I-SPY 2 trial for breast cancer. VC showed improved efficacy in the triple negative signature. However, not all triple negative patients achieved pathologic complete response and some HR+...

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Publicado no:NPJ Breast Cancer
Main Authors: Wolf, Denise M., Yau, Christina, Sanil, Ashish, Glas, Annuska, Petricoin, Emanuel, Wulfkuhle, Julia, Severson, Tesa M., Linn, Sabine, Brown-Swigart, Lamorna, Hirst, Gillian, Buxton, Meredith, DeMichele, Angela, Hylton, Nola, Symmans, Fraser, Yee, Doug, Paoloni, Melissa, Esserman, Laura, Berry, Don, Rugo, Hope, Olopade, Olufunmilayo, van ‘t Veer, Laura
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5572474/
https://ncbi.nlm.nih.gov/pubmed/28948212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41523-017-0025-7
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