Engineered Fc-glycosylation switch to eliminate antibody effector function

Antibodies mediate effector functions through Fcγ receptor (FcγR) interactions and complement activation, causing cytokine release, degranulation, phagocytosis, and cell death. They are often undesired for development of therapeutic antibodies where only antigen binding or neutralization would be id...

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Detaylı Bibliyografya
Yayımlandı:MAbs
Asıl Yazarlar: Zhou, Qun, Jaworski, Julie, Zhou, Yanfeng, Valente, Delphine, Cotton, Joanne, Honey, Denise, Boudanova, Ekaterina, Beninga, Jochen, Rao, Ercole, Wei, Ronnie, Mauriac, Christine, Pan, Clark, Park, Anna, Qiu, Huawei
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Taylor & Francis 2020
Konular:
Report
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7531572/
https://ncbi.nlm.nih.gov/pubmed/32892677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2020.1814583
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