CD40- and CD95-specific antibody single chain-Baff fusion proteins display BaffR-, TACI- and BCMA-restricted agonism

Antibodies that target a clinically relevant group of receptors within the tumor necrosis factor receptor superfamily (TNFRSF), including CD40 and CD95 (Fas/Apo-1), also require binding to Fc gamma receptors (FcγRs) to elicit a strong agonistic activity. This FcγR dependency largely relies on the me...

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Publicado no:MAbs
Main Authors: Nelke, Johannes, Medler, Juliane, Weisenberger, Daniela, Beilhack, Andreas, Wajant, Harald
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7531569/
https://ncbi.nlm.nih.gov/pubmed/32840410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2020.1807721
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