CD40- and CD95-specific antibody single chain-Baff fusion proteins display BaffR-, TACI- and BCMA-restricted agonism

Antibodies that target a clinically relevant group of receptors within the tumor necrosis factor receptor superfamily (TNFRSF), including CD40 and CD95 (Fas/Apo-1), also require binding to Fc gamma receptors (FcγRs) to elicit a strong agonistic activity. This FcγR dependency largely relies on the me...

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Autores principales: Johannes Nelke, Juliane Medler, Daniela Weisenberger, Andreas Beilhack, Harald Wajant
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis Group 2020-01-01
Colección:mAbs
Materias:
Antibody fusion protein
bifunctional
CD40
CD95
TNFRSF
Acceso en línea:https://www.tandfonline.com/doi/10.1080/19420862.2020.1807721
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