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Affinity maturation of antibodies by combinatorial codon mutagenesis versus error-prone PCR
In vitro affinity maturation of therapeutic monoclonal antibodies is commonly applied to achieve desired properties, such as improved binding kinetics and affinity. Currently there are no universally accepted protocols for generation of variegated antibody libraries or selection thereof. Here, we pe...
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| Publié dans: | MAbs |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Taylor & Francis
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7531523/ https://ncbi.nlm.nih.gov/pubmed/32744131 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2020.1803646 |
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