Matrix Metalloproteinase-12 Is Required for Granuloma Progression

BACKGROUND: Sarcoidosis is a chronic inflammatory disease of unknown cause characterized by granuloma formation. Mechanisms for chronic persistence of granulomas are unknown. Matrix Metalloproteinase-12 (MMP12) degrades extracellular matrix elastin and enables infiltration of immune cells responsibl...

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Udgivet i:Front Immunol
Main Authors: Mohan, Arjun, Neequaye, Nicole, Malur, Anagha, Soliman, Eman, McPeek, Matthew, Leffler, Nancy, Ogburn, David, Tokarz, Debra A., Knudson, Warren, Gharib, Sina A., Schnapp, Lynn M., Barna, Barbara P., Thomassen, Mary Jane
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7531023/
https://ncbi.nlm.nih.gov/pubmed/33072094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.553949
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