Abivertinib synergistically strengthens the anti‐leukemia activity of venetoclax in acute myeloid leukemia in a BTK‐dependent manner

B‐cell lymphoma 2 (BCL‐2), a crucial member of the anti‐apoptotic BCL‐2 family, is frequently dysregulated in cancer and plays an important role in acute myeloid leukemia (AML). Venetoclax is a highly selective BCL‐2 inhibitor that has been approved by the FDA for treating elderly AML patients. Howe...

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Bibliographic Details
Published in:Mol Oncol
Main Authors: Huang, Shujuan, Li, Chenying, Zhang, Xiang, Pan, Jiajia, Li, Fenglin, Lv, Yunfei, Huang, Jingwen, Ling, Qing, Ye, Wenle, Mao, Shihui, Huang, Xin, Jin, Jie
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2020
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7530784/
https://ncbi.nlm.nih.gov/pubmed/32519423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12742
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