Treating neutropenia and neutrophil dysfunction in glycogen storage disease type Ib with an SGLT2 inhibitor

Neutropenia and neutrophil dysfunction cause serious infections and inflammatory bowel disease in glycogen storage disease type Ib (GSD-Ib). Our discovery that accumulating 1,5-anhydroglucitol-6-phosphate (1,5AG6P) caused neutropenia in a glucose-6-phosphatase 3 (G6PC3)–deficient mouse model and in...

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Bibliographic Details
Published in:Blood
Main Authors: Wortmann, Saskia B., Van Hove, Johan L. K., Derks, Terry G. J., Chevalier, Nathalie, Knight, Vijaya, Koller, Andreas, Oussoren, Esmee, Mayr, Johannes A., van Spronsen, Francjan J., Lagler, Florian B., Gaughan, Sommer, Van Schaftingen, Emile, Veiga-da-Cunha, Maria
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2020
Subjects:
Clinical Trials and Observations
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7530374/
https://ncbi.nlm.nih.gov/pubmed/32294159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019004465
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