Neural Transplants From Human Induced Pluripotent Stem Cells Rescue the Pathology and Behavioral Defects in a Rodent Model of Huntington’s Disease

Huntington’s disease (HD) is a devastating, autosomal-dominant inheritance disorder with the progressive loss of medium spiny neurons (MSNs) and corticostriatal connections in the brain. Cell replacement therapy has been proposed as a potential therapeutic strategy to treat HD. Among various types o...

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Vydáno v:Front Neurosci
Hlavní autoři: Yoon, Yongwoo, Kim, Hyun Sook, Hong, Chang Pyo, Li, Endan, Jeon, Iksoo, Park, Hyun Jung, Lee, Nayeon, Pei, Zhong, Song, Jihwan
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020
Témata:
Neuroscience
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7530284/
https://ncbi.nlm.nih.gov/pubmed/33071737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2020.558204
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