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Discovery of Quorum Quenchers Targeting the Membrane-embedded Sensor Domain of the Staphylococcus aureus Receptor Histidine Kinase, AgrC
We combined mRNA display technology with lipid-nanodisc based selections and identified high-affinity ligands targeting the integral membrane sensor domain of the histidine kinase AgrC as potent inhibitors of Staphylococcus aureus quorum sensing-modulated virulence. Our study highlights the potentia...
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| Publicat a: | Chem Commun (Camb) |
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| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7530097/ https://ncbi.nlm.nih.gov/pubmed/32820778 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0cc04873a |
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