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LptB-LptF coupling mediates closure of the substrate-binding cavity in the LptB(2)FGC transporter through a rigid-body mechanism to extract LPS

Lipopolysaccharides (LPS) are essential envelope components in many Gram-negative bacteria and provide intrinsic resistance to antibiotics. LPS molecules are synthesized in the inner membrane and then transported to the cell surface by the LPS transport (Lpt) machinery. In this system, the ATP-bindi...

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Detalhes bibliográficos
Publicado no:Mol Microbiol
Main Authors: Lundstedt, Emily A., Simpson, Brent W., Ruiz, Natividad
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7529706/
https://ncbi.nlm.nih.gov/pubmed/32236984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/mmi.14506
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