CRITICAL SIGNALING EVENTS IN THE MECHANOACTIVATION OF HUMAN MAST CELLS VIA P.C492Y-ADGRE2

A role for the adhesion G-protein coupled receptor ADGRE2 (EMR2) in mechanosensing was revealed by the finding of a missense substitution (p.C492Y) associated with familial vibratory urticaria (VU). In these patients, friction of the skin induces mast cell hyper-degranulation through p.C492Y-ADGRE2,...

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Gepubliceerd in:J Invest Dermatol
Hoofdauteurs: Naranjo, Andrea N., Bandara, Geethani, Bai, Yun, Smelkinson, Margery G., Tobío, Araceli, Komarow, Hirsh D., Boyden, Steven E., Kastner, Daniel L., Metcalfe, Dean D., Olivera, Ana
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7529699/
https://ncbi.nlm.nih.gov/pubmed/32222457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jid.2020.03.936
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