Nonlinearities between inhibition and T-type calcium channel activity bidirectionally regulate thalamic oscillations

Absence seizures result from 3 to 5 Hz generalized thalamocortical oscillations that depend on highly regulated inhibitory neurotransmission in the thalamus. Efficient reuptake of the inhibitory neurotransmitter GABA is essential, and reuptake failure worsens human seizures. Here, we show that block...

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Dades bibliogràfiques
Publicat a:eLife
Autors principals: Lu, Adam C, Lee, Christine Kyuyoung, Kleiman-Weiner, Max, Truong, Brian, Wang, Megan, Huguenard, John R, Beenhakker, Mark P
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2020
Matèries:
Computational and Systems Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7529462/
https://ncbi.nlm.nih.gov/pubmed/32902384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.59548
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