Lamin microaggregates lead to altered mechanotransmission in progerin-expressing cells

The nuclear lamina is a meshwork of intermediate filament proteins, and lamin A is the primary mechanical protein. An altered splicing of lamin A, known as progerin, causes the disease Hutchinson-Gilford progeria syndrome. Progerin-expressing cells have altered nuclear shapes and stiffened nuclear l...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nucleus
Prif Awduron: Danielsson, Brooke E., Tieu, Katie V., Bathula, Kranthidhar, Armiger, Travis J., Vellala, Pragna S., Taylor, Rebecca E., Dahl, Kris Noel, Conway, Daniel E.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Taylor & Francis 2020
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7529416/
https://ncbi.nlm.nih.gov/pubmed/32816594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19491034.2020.1802906
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