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Depletion of adipocyte sphingosine kinase 1 leads to cell hypertrophy, impaired lipolysis, and nonalcoholic fatty liver disease
Sphingolipids have become established participants in the pathogenesis of obesity and its associated maladies. Sphingosine kinase 1 (SPHK1), which generates S1P, has been shown to increase in liver and adipose of obese humans and mice and to regulate inflammation in hepatocytes and adipose tissue, i...
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| Vydáno v: | J Lipid Res |
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| Hlavní autoři: | , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
The American Society for Biochemistry and Molecular Biology
2020
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7529052/ https://ncbi.nlm.nih.gov/pubmed/32690594 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.RA120000875 |
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