Deubiquitinase USP20 promotes breast cancer metastasis by stabilizing SNAI2

SNAI2/SLUG, a metastasis-promoting transcription factor, is a labile protein that is degraded through the ubiquitin proteasome degradation system. Here, we conducted comprehensive gain- and loss-of-function screens using a human DUB cDNA library of 65 genes and an siRNA library of 98 genes, and iden...

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Publicat a:Genes Dev
Autors principals: Li, Wenyang, Shen, Minhong, Jiang, Yi-Zhou, Zhang, Ruina, Zheng, Hanqiu, Wei, Yong, Shao, Zhi-Ming, Kang, Yibin
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2020
Matèries:
Research Communication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7528704/
https://ncbi.nlm.nih.gov/pubmed/32943575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.339804.120
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