Deubiquitinase USP20 promotes breast cancer metastasis by stabilizing SNAI2

SNAI2/SLUG, a metastasis-promoting transcription factor, is a labile protein that is degraded through the ubiquitin proteasome degradation system. Here, we conducted comprehensive gain- and loss-of-function screens using a human DUB cDNA library of 65 genes and an siRNA library of 98 genes, and iden...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Genes Dev
Hauptverfasser: Li, Wenyang, Shen, Minhong, Jiang, Yi-Zhou, Zhang, Ruina, Zheng, Hanqiu, Wei, Yong, Shao, Zhi-Ming, Kang, Yibin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2020
Schlagworte:
Research Communication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7528704/
https://ncbi.nlm.nih.gov/pubmed/32943575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.339804.120
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge