Incidence of Succinate Dehydrogenase and Fumarate Hydratase-Deficient Renal Cell Carcinoma Based on Immunohistochemical Screening with SDHA/SDHB and FH/2SC

Mutations of the succinate dehydrogenase (SDHX) enzyme subunits commonly lead to a loss of function of the holoenzyme complex, and germline SDHX mutations lead to a genetic predisposition to SDH-deficient neoplasms, including renal cell carcinomas (RCC). Similarly, loss of function alterations of fu...

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Publicado en:Hum Pathol
Autores principales: Gupta, Sounak, Swanson, Amy A., Chen, Ying-Bei, Lopez, Tilcia, Milosevic, Dragana, Kipp, Benjamin R., Leibovich, Bradley C., Thompson, R. Houston, Herrera-Hernandez, Loren, Cheville, John C., Jimenez, Rafael E.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7528421/
https://ncbi.nlm.nih.gov/pubmed/31299266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.humpath.2019.07.004
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