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Increased Number and Activity of a Lateral Subpopulation of Hypothalamic Orexin/Hypocretin Neurons Underlies the Expression of an Addicted State in Rats

BACKGROUND: The orexin (hypocretin) system is important for reward-driven motivation but has not been implicated in the expression of a multiphenotype addicted state. METHODS: Rats were assessed for economic demand for cocaine before and after 14 days of short access, long access, or intermittent ac...

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Detalhes bibliográficos
Publicado no:Biol Psychiatry
Main Authors: James, Morgan H., Stopper, Colin M., Zimmer, Benjamin A., Koll, Nikki E., Bowrey, Hannah E., Aston-Jones, Gary
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7528037/
https://ncbi.nlm.nih.gov/pubmed/30219208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2018.07.022
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